Covid-19
is here to stay1
Immunocompromised people have multiple options for protection.2
Get More Information
Call 844-893-2220
COVID-19 numbers speak
for themselves
~530,000
Hospitalizations3*
~48,000
Deaths4†
* Estimated from January 6, 2024, through December 28, 2024.
† Cumulative number of deaths from January 6, 2024 through January 4, 2025.
Immunocompromised people may need more protection against COVID-195
Immunocompromised people may be more vulnerable to COVID-19, because they may have a weaker response to COVID-19 vaccines. Immunocompromised people are also at increased risk of severe COVID-19-related illness and death.6
Practice These Prevention Strategies2,7
Encourage practicing extra precaution
Help reduce the spread of COVID-19
Stay up to date with COVID-19 vaccination
Learn about other prevention options
Immunocompromised people may need more protection against COVID-195
Immunocompromised people may be more vulnerable to COVID-19, because they may have a weaker response to COVID-19 vaccines. Immunocompromised people are also at increased risk of severe COVID-19-related illness and death.6
Practice These Prevention Strategies2,7
Encourage practicing extra precaution
Help reduce the spread of COVID-19
Stay up to date with COVID-19 vaccination
Learn about other prevention options
Understand COVID-19 Protection
The CDC recommends combining multiple paths of protection against COVID-19 for immunocompromised people.8
Exploring COVID-19 prevention options in immunocompromised people
The CDC recommends combining multiple paths of protection against COVID-19 for immunocompromised people.8
Exploring COVID-19
prevention options in
immunocompromised people
Vaccine9
May help provide protection, but immunocompromised people may have a reduced response.10
Triggers an immune response by teaching the body how to produce SARS-CoV-2 specific antibodies
Primes the body to recognize and fight infections
Can build long-term immunity over time
Monoclonal Antibody11,12
May provide protection by helping to boost the immune system's response to the virus that causes COVID-19.13
Molecule designed to help protect by mimicking or enhancing the natural immune response
Targets specific viral proteins, inhibiting binding to host cells
May offer immediate protection, yet the duration of potential effectiveness may vary
Seeking protection
against COVID-19
Immunity to COVID-19 may be achieved through the presence of disease-specific antibodies.14 This immunity can be classified as active, where the body is directly involved in producing protection, or as passive, where protection comes from an external source.15
Examples of Active Immunity15
Natural
A person’s immune system makes antibodies after being exposed to an infection
Artificial
A person’s immune system makes antibodies after receiving a vaccine
Examples of Passive Immunity15
Natural
Comes from the mother, as she transmits antibodies to a baby
Artificial
A medicine delivers antibodies to a person’s body
Ask Your Doctor
Talking with a doctor is an important first step for immunocompromised people to understand COVID-19 protection options.
Resources
Download Patient Brochure
COVID-19 Resources
CDC: Updated COVID-19 ACIP Vaccination Recommendations
CDC: People with Certain Medical Conditions and COVID-19 Risk Factors
Links provided lead to external websites and are provided as a courtesy for informational purposes only.
References
ACIP, Advisory Committee on Immunization Practices; CDC, Centers for Disease Control and Prevention; COVID-19, coronavirus disease 2019
- CDC. Surveillance and Data Analytics. COVID-19. Published September 5, 2025. Updated 2025. Accessed January 22, 2026. https://www.cdc.gov/covid/php/surveillance/index.html
- CDC. COVID-19: How to Protect Yourself and Others. Accessed February 3, 2026. https://www.cdc.gov/covid/prevention/index.html
- CDC. Rates of laboratory-confirmed COVID-19 hospitalizations from the RESP-NET surveillance systems (COVID-NET). Accessed May 29, 2025. https://data.cdc.gov/Public-Health-Surveillance/Rates-of-Laboratory-Confirmed-RSV-COVID-19-and-Flu/kvib-3txy
- CDC. COVID Data Tracker. Accessed May 29, 2025. https://covid.cdc.gov/covid-data-tracker/#trends_weeklydeaths_select_00
- Wang L, Wang Q, Davis PB, Volkow ND, Xu R. Prevalence of immunosuppression among US adults. JAMA. 2024;331(6):531-533. doi:10.1001/jama.2024.2815274
- CDC. COVID-19: People with certain medical conditions. Accessed December 18, 2025. https://www.cdc.gov/covid/risk-factors/index.html
- US Centers for Medicare & Medicaid Services. COVID-19 monoclonal antibodies. Accessed December 18, 2025. https://www.cms.gov/monoclonal
- CDC. Underlying Conditions and the Higher Risk for Severe COVID-19. COVID-19. Published February 6, 2025. Accessed January 22, 2026. https://www.cdc.gov/covid/hcp/clinical-care/underlying-conditions.html
- CDC. Explaining how vaccines work. Accessed December 18, 2025. https://www.cdc.gov/vaccines/basics/explaining-how-vaccines-work.html
- Pearce FA, Lim SH, Bythell M, et al. Antibody prevalence after three or more COVID-19 vaccine doses in individuals who are immunosuppressed in the UK: a cross-sectional study from MELODY. Lancet Rheumatol. 2023;5(8):e461-e473. doi:10.1016/S2665-9913(23)00160-1
- Chary M, Barbuto AF, Izadmehr S, Tarsillo M, Fleischer E, Burns MM. COVID-19 Therapeutics: Use, Mechanism of Action, and Toxicity (Vaccines, Monoclonal Antibodies, and Immunotherapeutics). J Med Toxicol. 2023;19(2):205-218. doi:10.1007/s13181-023-00931-9
- Lloyd EC, Gandhi TN, Petty LA. Monoclonal Antibodies for COVID-19. JAMA. 2021;325(10):1015. doi:10.1001/jama.2021.1225
- Cowan J, Amson A, Christofides A, Chagla Z. Monoclonal antibodies as COVID-19 prophylaxis therapy in immunocompromised patient populations. Int J Infect Dis. 2023;134:228-238. doi:10.1016/j.ijid.2023.06.021
- Scourfield DO, Reed SG, Quastel M, et al. The role and uses of antibodies in COVID-19 infections: a living review. Oxf Open Immunol. 2021;2(1):iqab003. Published 2021 Jan 28. doi:10.1093/oxfimm/iqab003
- CDC. Types of immunity & how vaccines work. Accessed December 18, 2025. https://www.cdc.gov/vaccines/basics/immunity-types.html